Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5346

A sealed prediction that did not hold.

did not replicate (discovery -0.88 p 0.0016; held-out -0.01 p 0.982). This receipt's hash covers every field on it, plus the hash of receipt 5345, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5346
    21 Oct 2026, 13:15 UTC

    CYB561

    dopamine neurons, braak

    predictionCYB561 in dopamine neurons tracks Braak Lewy-body stage

    registered35fe31c361e60d40

    discovery-0.88 p=0.0016 n=9

    replication-0.01 p=0.982 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.88 p 0.0016; held-out -0.01 p 0.982)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    9b3f96661538b40c1b327b18…
    follows 89f34ba7478a…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5346: CYB561 in dopamine neurons, braak

power
full sample -0.45 (p 0.059, n 18), 95% CI -0.76 to +0.02. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.45 (p 0.062, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.022, n 18). not the mix.
skeptic
leave-one-out range -0.59 to -0.38, sign flips 0; without severely affected donors -0.45 (p 0.059, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CYB561 in dopamine neurons.

case closed: nothing better to follow up.