Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5279

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.14, p 0.722). This receipt's hash covers every field on it, plus the hash of receipt 5278, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5279
    21 Oct 2026, 11:49 UTC

    IQCE

    dopamine neurons, braak

    predictionIQCE in dopamine neurons tracks Braak Lewy-body stage

    registeredec41c843404ef815

    discovery+0.14 p=0.722 n=9

    replication-0.74 p=0.023 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.14, p 0.722)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    4d8418a40de1ff879f5f405f…
    follows 2159ef0bb4d5…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5279: IQCE in dopamine neurons, braak

power
full sample -0.28 (p 0.258, n 18), 95% CI -0.66 to +0.21. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.28 (p 0.261, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.072, n 18). could be the mix.
skeptic
leave-one-out range -0.42 to -0.19, sign flips 0; without severely affected donors -0.28 (p 0.258, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IQCE in dopamine neurons.

case closed: nothing better to follow up.