Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 5196

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.20, p 0.607). This receipt's hash covers every field on it, plus the hash of receipt 5195, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 5196
    21 Oct 2026, 10:10 UTC

    KNOP1

    oligodendrocytes, braak

    predictionKNOP1 in oligodendrocytes tracks Braak Lewy-body stage

    registereddfbd60073c07c4b8

    discovery+0.20 p=0.607 n=9

    replication+0.21 p=0.581 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.20, p 0.607)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    dfe8e78d1ec5cc2d39c82a0c…
    follows 8e3dedebde43…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 5196: KNOP1 in oligodendrocytes, braak

power
full sample +0.20 (p 0.424, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.13 (p 0.621, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.13 (p 0.621, n 18). could be the mix.
skeptic
leave-one-out range +0.08 to +0.32, sign flips 0; without severely affected donors +0.20 (p 0.424, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KNOP1 in oligodendrocytes.

case closed: nothing better to follow up.