Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4808

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.22, p 0.571). This receipt's hash covers every field on it, plus the hash of receipt 4807, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4808
    21 Oct 2026, 02:14 UTC

    EFNB3

    dopamine neurons, braak

    predictionEFNB3 in dopamine neurons tracks Braak Lewy-body stage

    registeredc8347d026f73ee16

    discovery-0.22 p=0.571 n=9

    replication-0.30 p=0.438 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.22, p 0.571)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    efab9149ca215141efd1a8c7…
    follows 56d5f9c7fe78…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4808: EFNB3 in dopamine neurons, braak

power
full sample -0.40 (p 0.097, n 18), 95% CI -0.73 to +0.08. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.43 (p 0.075, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.58 (p 0.012, n 18). not the mix.
skeptic
leave-one-out range -0.57 to -0.33, sign flips 0; without severely affected donors -0.40 (p 0.097, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for EFNB3 in dopamine neurons.

case closed: nothing better to follow up.