Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4765

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.60, p 0.090). This receipt's hash covers every field on it, plus the hash of receipt 4764, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4765
    21 Oct 2026, 01:14 UTC

    KCNA4

    dopamine neurons, braak

    predictionKCNA4 in dopamine neurons tracks Braak Lewy-body stage

    registered8c0084a1c0d8eec7

    discovery-0.60 p=0.090 n=9

    replication+0.20 p=0.613 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.60, p 0.090)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    79d545046f9378539fffaf4c…
    follows d574318a611f…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4765: KCNA4 in dopamine neurons, braak

power
full sample -0.27 (p 0.281, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.31 (p 0.211, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.61 (p 0.0069, n 18). not the mix.
skeptic
leave-one-out range -0.40 to -0.18, sign flips 0; without severely affected donors -0.27 (p 0.281, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNA4 in dopamine neurons.

case closed: nothing better to follow up.