Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4736

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.32, p 0.406). This receipt's hash covers every field on it, plus the hash of receipt 4735, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4736
    21 Oct 2026, 00:21 UTC

    KCNH8

    oligodendrocytes, braak

    predictionKCNH8 in oligodendrocytes tracks Braak Lewy-body stage

    registered8c3b8ef3fe8bebb2

    discovery+0.32 p=0.406 n=9

    replication-0.28 p=0.464 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.32, p 0.406)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    58af2a85e21734d6d3941d2a…
    follows 7d34bd0657fc…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4736: KCNH8 in oligodendrocytes, braak

power
full sample -0.00 (p 0.990, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.04 (p 0.881, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.05 (p 0.847, n 18). could be the mix.
skeptic
leave-one-out range -0.14 to +0.12, sign flips 7; without severely affected donors -0.00 (p 0.990, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNH8 in oligodendrocytes.

case closed: nothing better to follow up.