Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4613

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.34, p 0.375). This receipt's hash covers every field on it, plus the hash of receipt 4612, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4613
    20 Oct 2026, 21:28 UTC

    GFY

    dopamine neurons, braak

    predictionGFY in dopamine neurons tracks Braak Lewy-body stage

    registered7cecc54aab64a76a

    discovery-0.34 p=0.375 n=9

    replication-0.45 p=0.230 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.34, p 0.375)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d9acd617baeba270ff0ec1a4…
    follows 2a973b313b61…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4613: GFY in dopamine neurons, braak

power
full sample -0.43 (p 0.079, n 18), 95% CI -0.74 to +0.05. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.43 (p 0.074, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.56 (p 0.015, n 18). not the mix.
skeptic
leave-one-out range -0.60 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.079, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GFY in dopamine neurons.

case closed: nothing better to follow up.