Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4497

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.07, p 0.856). This receipt's hash covers every field on it, plus the hash of receipt 4496, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4497
    20 Oct 2026, 18:54 UTC

    SHISA7

    oligodendrocytes, braak

    predictionSHISA7 in oligodendrocytes tracks Braak Lewy-body stage

    registeredc23793db28613666

    discovery+0.07 p=0.856 n=9

    replication+0.05 p=0.891 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.07, p 0.856)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ff27ee137bb2a74acbb0481b…
    follows 94a1516bde06…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4497: SHISA7 in oligodendrocytes, braak

power
full sample +0.10 (p 0.683, n 18), 95% CI -0.38 to +0.54. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.19 (p 0.450, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.30 (p 0.232, n 18). could be the mix.
skeptic
leave-one-out range -0.03 to +0.25, sign flips 1; without severely affected donors +0.10 (p 0.683, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SHISA7 in oligodendrocytes.

case closed: nothing better to follow up.