Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4485

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.09, p 0.815). This receipt's hash covers every field on it, plus the hash of receipt 4484, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4485
    20 Oct 2026, 18:37 UTC

    ARRB1

    microglia, braak

    predictionARRB1 in microglia tracks Braak Lewy-body stage

    registered15cd1bd68837d085

    discovery-0.09 p=0.815 n=9

    replication-0.43 p=0.253 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.09, p 0.815)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2c1a49f5c20e6d6d6a7416c7…
    follows 9b880af3e716…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4485: ARRB1 in microglia, braak

power
full sample -0.37 (p 0.132, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.37 (p 0.132, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.29 (p 0.246, n 18). could be the mix.
skeptic
leave-one-out range -0.54 to -0.30, sign flips 0; without severely affected donors -0.37 (p 0.132, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ARRB1 in microglia.

case closed: nothing better to follow up.