Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4483

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.11, p 0.775). This receipt's hash covers every field on it, plus the hash of receipt 4482, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4483
    20 Oct 2026, 18:35 UTC

    FBN2

    dopamine neurons, braak

    predictionFBN2 in dopamine neurons tracks Braak Lewy-body stage

    registeredf3f806ebd56d4172

    discovery+0.11 p=0.775 n=9

    replication+0.84 p=0.0049 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.11, p 0.775)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d0d251c6480192b13409f03a…
    follows da3d5108ee40…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4483: FBN2 in dopamine neurons, braak

power
full sample +0.48 (p 0.042, n 18), 95% CI +0.02 to +0.78. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.45 (p 0.063, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.070, n 18). could be the mix.
skeptic
leave-one-out range +0.41 to +0.63, sign flips 0; without severely affected donors +0.48 (p 0.042, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FBN2 in dopamine neurons.

case closed: nothing better to follow up.