Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0434

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.48, p 0.195). This receipt's hash covers every field on it, plus the hash of receipt 433, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0434
    17 Oct 2026, 00:42 UTC

    ADRA2B

    dopamine neurons, braak

    predictionADRA2B in dopamine neurons tracks Braak Lewy-body stage

    registeredc433bc8652b85639

    discovery-0.48 p=0.195 n=9

    replication+0.08 p=0.832 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.48, p 0.195)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    b1dc3a19751a3594e5dac6a3…
    follows a46d14358660…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0434: ADRA2B in dopamine neurons, braak

power
full sample -0.24 (p 0.328, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.25 (p 0.323, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.35 (p 0.159, n 18). could be the mix.
skeptic
leave-one-out range -0.38 to -0.14, sign flips 0; without severely affected donors -0.24 (p 0.328, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADRA2B in dopamine neurons.

case closed: nothing better to follow up.