Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4139

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.26, p 0.502). This receipt's hash covers every field on it, plus the hash of receipt 4138, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4139
    20 Oct 2026, 10:46 UTC

    KCNN4

    dopamine neurons, braak

    predictionKCNN4 in dopamine neurons tracks Braak Lewy-body stage

    registeredb67924780123de0c

    discovery-0.26 p=0.502 n=9

    replication-0.10 p=0.807 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.26, p 0.502)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    5bae6b4abf4c43df0fca1ea9…
    follows 421eab09d27e…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4139: KCNN4 in dopamine neurons, braak

power
full sample -0.21 (p 0.413, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.22 (p 0.384, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.125, n 18). could be the mix.
skeptic
leave-one-out range -0.35 to -0.11, sign flips 0; without severely affected donors -0.21 (p 0.413, n 18). fragile.
cell type
strongest in microglia: -0.63 (p 0.0051, n 18) vs -0.21 in dopamine neurons. proposing microglia.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNN4 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up KCNN4 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.55 p 0.051 (needs p < 4.8e-4)