Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 4022

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.33, p 0.388). This receipt's hash covers every field on it, plus the hash of receipt 4021, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 4022
    20 Oct 2026, 08:06 UTC

    CELA2A

    dopamine neurons, braak

    predictionCELA2A in dopamine neurons tracks Braak Lewy-body stage

    registeredf0896b64a19e44c3

    discovery+0.33 p=0.388 n=9

    replication-0.25 p=0.521 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.33, p 0.388)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    1b72ea07dfed5cd48ed7e1fd…
    follows 10ab8b372194…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 4022: CELA2A in dopamine neurons, braak

power
full sample -0.12 (p 0.633, n 18), 95% CI -0.56 to +0.37. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.15 (p 0.555, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.15 (p 0.549, n 18). could be the mix.
skeptic
leave-one-out range -0.25 to -0.01, sign flips 0; without severely affected donors -0.12 (p 0.633, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CELA2A in dopamine neurons.

case closed: nothing better to follow up.