Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0393

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.26, p 0.499). This receipt's hash covers every field on it, plus the hash of receipt 392, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0393
    16 Oct 2026, 23:38 UTC

    AP2S1

    dopamine neurons, braak

    predictionAP2S1 in dopamine neurons tracks Braak Lewy-body stage

    registeredfb9286fbfb1105c2

    discovery+0.26 p=0.499 n=9

    replication+0.34 p=0.373 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.26, p 0.499)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3d4a9ea6486ae684492cb5f8…
    follows d817b3a26c40…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0393: AP2S1 in dopamine neurons, braak

power
full sample +0.27 (p 0.273, n 18), 95% CI -0.22 to +0.66. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.30 (p 0.221, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.32 (p 0.191, n 18). could be the mix.
skeptic
leave-one-out range +0.17 to +0.40, sign flips 0; without severely affected donors +0.27 (p 0.273, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for AP2S1 in dopamine neurons.

case closed: nothing better to follow up.