Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0388

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.26, p 0.504). This receipt's hash covers every field on it, plus the hash of receipt 387, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0388
    16 Oct 2026, 23:30 UTC

    NUP205

    dopamine neurons, braak

    predictionNUP205 in dopamine neurons tracks Braak Lewy-body stage

    registered3d80769fb1ce1a8b

    discovery+0.26 p=0.504 n=9

    replication-0.03 p=0.939 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.26, p 0.504)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d9bbb7e48387b32310ea9a5f…
    follows 93699475d77a…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0388: NUP205 in dopamine neurons, braak

power
full sample +0.22 (p 0.379, n 18), 95% CI -0.27 to +0.62. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.30 (p 0.225, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.31 (p 0.204, n 18). could be the mix.
skeptic
leave-one-out range +0.13 to +0.37, sign flips 0; without severely affected donors +0.22 (p 0.379, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NUP205 in dopamine neurons.

case closed: nothing better to follow up.