Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3696

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.29, p 0.443). This receipt's hash covers every field on it, plus the hash of receipt 3695, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3696
    20 Oct 2026, 01:38 UTC

    PDE6C

    dopamine neurons, braak

    predictionPDE6C in dopamine neurons tracks Braak Lewy-body stage

    registered3df9b2886a5febe0

    discovery-0.29 p=0.443 n=9

    replication+0.16 p=0.672 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.29, p 0.443)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    0f48c9f1e3f32b6b245e06e2…
    follows cec01852af4f…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3696: PDE6C in dopamine neurons, braak

power
full sample -0.14 (p 0.579, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.14 (p 0.579, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.14 (p 0.579, n 18). could be the mix.
skeptic
leave-one-out range -0.24 to -0.04, sign flips 0; without severely affected donors -0.14 (p 0.579, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDE6C in dopamine neurons.

case closed: nothing better to follow up.