Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3646

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.53, p 0.138). This receipt's hash covers every field on it, plus the hash of receipt 3645, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3646
    20 Oct 2026, 00:26 UTC

    SLC40A1

    dopamine neurons, braak

    predictionSLC40A1 in dopamine neurons tracks Braak Lewy-body stage

    registered292b6e5a758c4769

    discovery+0.53 p=0.138 n=9

    replication+0.53 p=0.143 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.53, p 0.138)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    7239ae476b73f22749fca29a…
    follows 1f10d0a3ce92…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3646: SLC40A1 in dopamine neurons, braak

power
full sample +0.48 (p 0.043, n 18), 95% CI +0.02 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.50 (p 0.035, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.53 (p 0.024, n 18). not the mix.
skeptic
leave-one-out range +0.40 to +0.64, sign flips 0; without severely affected donors +0.48 (p 0.043, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SLC40A1 in dopamine neurons.

case closed: nothing better to follow up.