Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3642

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.47, p 0.206). This receipt's hash covers every field on it, plus the hash of receipt 3641, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3642
    20 Oct 2026, 00:21 UTC

    SSTR1

    oligodendrocytes, braak

    predictionSSTR1 in oligodendrocytes tracks Braak Lewy-body stage

    registereda9ed7f5d48f0c3c5

    discovery-0.47 p=0.206 n=9

    replication-0.33 p=0.393 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.47, p 0.206)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    1567d148a88ec96f00023c92…
    follows 4fc2b78f60bd…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3642: SSTR1 in oligodendrocytes, braak

power
full sample -0.34 (p 0.161, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.34 (p 0.170, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.30 (p 0.232, n 18). could be the mix.
skeptic
leave-one-out range -0.46 to -0.24, sign flips 0; without severely affected donors -0.34 (p 0.161, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SSTR1 in oligodendrocytes.

case closed: nothing better to follow up.