Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0363

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.37, p 0.331). This receipt's hash covers every field on it, plus the hash of receipt 362, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0363
    16 Oct 2026, 22:57 UTC

    ZNF207

    dopamine neurons, braak

    predictionZNF207 in dopamine neurons tracks Braak Lewy-body stage

    registered84d73e9fe7e3f777

    discovery+0.37 p=0.331 n=9

    replication+0.26 p=0.500 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.37, p 0.331)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    cf99f0a74ffd1f3ee7e6ac67…
    follows f963ccbac421…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0363: ZNF207 in dopamine neurons, braak

power
full sample +0.29 (p 0.235, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.29 (p 0.243, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.137, n 18). could be the mix.
skeptic
leave-one-out range +0.21 to +0.39, sign flips 0; without severely affected donors +0.29 (p 0.235, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ZNF207 in dopamine neurons.

case closed: nothing better to follow up.