Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3390

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.23, p 0.549). This receipt's hash covers every field on it, plus the hash of receipt 3389, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3390
    19 Oct 2026, 18:53 UTC

    TUBB4A

    oligodendrocytes, braak

    predictionTUBB4A in oligodendrocytes tracks Braak Lewy-body stage

    registereda46a19f9e03110e8

    discovery+0.23 p=0.549 n=9

    replication-0.22 p=0.576 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.23, p 0.549)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    51952251af4a5a70dd1454e7…
    follows 11ca6338059c…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3390: TUBB4A in oligodendrocytes, braak

power
full sample +0.01 (p 0.969, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.969, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.01 (p 0.976, n 18). could be the mix.
skeptic
leave-one-out range -0.09 to +0.14, sign flips 6; without severely affected donors +0.01 (p 0.969, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TUBB4A in oligodendrocytes.

case closed: nothing better to follow up.