Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 3071

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.53, p 0.138). This receipt's hash covers every field on it, plus the hash of receipt 3070, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 3071
    19 Oct 2026, 11:41 UTC

    S100A9

    dopamine neurons, braak

    predictionS100A9 in dopamine neurons tracks Braak Lewy-body stage

    registerede4bd345d2a611ad9

    discovery-0.53 p=0.138 n=9

    replication+0.28 p=0.470 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.53, p 0.138)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    9ab0976f8ff0de13d4ef2efe…
    follows 6745c34bd1cb…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 3071: S100A9 in dopamine neurons, braak

power
full sample -0.00 (p 0.990, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.08 (p 0.761, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.08 (p 0.761, n 18). could be the mix.
skeptic
leave-one-out range -0.15 to +0.09, sign flips 13; without severely affected donors -0.00 (p 0.990, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for S100A9 in dopamine neurons.

case closed: nothing better to follow up.