Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2917

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.46, p 0.216). This receipt's hash covers every field on it, plus the hash of receipt 2916, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2917
    19 Oct 2026, 08:15 UTC

    RUNX3

    dopamine neurons, braak

    predictionRUNX3 in dopamine neurons tracks Braak Lewy-body stage

    registeredb01c3dcd18cb9986

    discovery-0.46 p=0.216 n=9

    replication-0.21 p=0.586 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.46, p 0.216)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2e16dc0456acb6329a1911ec…
    follows af9aa2214efc…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2917: RUNX3 in dopamine neurons, braak

power
full sample -0.36 (p 0.140, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.36 (p 0.140, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.069, n 18). could be the mix.
skeptic
leave-one-out range -0.48 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.140, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RUNX3 in dopamine neurons.

case closed: nothing better to follow up.