Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2878

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.51, p 0.163). This receipt's hash covers every field on it, plus the hash of receipt 2877, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2878
    19 Oct 2026, 07:20 UTC

    ZNF423

    dopamine neurons, braak

    predictionZNF423 in dopamine neurons tracks Braak Lewy-body stage

    registeredcdc92a94bb22dd60

    discovery-0.51 p=0.163 n=9

    replication-0.13 p=0.739 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.51, p 0.163)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    5a7860ea5c06c251437f44e2…
    follows 95525a3d4141…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2878: ZNF423 in dopamine neurons, braak

power
full sample -0.43 (p 0.072, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.43 (p 0.072, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.028, n 18). not the mix.
skeptic
leave-one-out range -0.60 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.072, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ZNF423 in dopamine neurons.

case closed: nothing better to follow up.