Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0253

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.04, p 0.909). This receipt's hash covers every field on it, plus the hash of receipt 252, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0253
    16 Oct 2026, 20:20 UTC

    MT-ND1

    dopamine neurons, braak

    predictionMT-ND1 in dopamine neurons tracks Braak Lewy-body stage

    registered3349fd961c7f4e86

    discovery+0.04 p=0.909 n=9

    replication+0.23 p=0.551 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.04, p 0.909)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3b86984771071c5091277d56…
    follows fd43534c2e81…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0253: MT-ND1 in dopamine neurons, braak

power
full sample +0.13 (p 0.621, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.13 (p 0.621, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.413, n 18). could be the mix.
skeptic
leave-one-out range +0.02 to +0.26, sign flips 0; without severely affected donors +0.13 (p 0.621, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MT-ND1 in dopamine neurons.

case closed: nothing better to follow up.