Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2486

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.36, p 0.341). This receipt's hash covers every field on it, plus the hash of receipt 2485, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2486
    18 Oct 2026, 23:06 UTC

    PARP1

    dopamine neurons, braak

    predictionPARP1 in dopamine neurons tracks Braak Lewy-body stage

    registeredeb9400751417b8f9

    discovery+0.36 p=0.341 n=9

    replication+0.05 p=0.893 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.36, p 0.341)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    778b9264a17f2c11e37d98e4…
    follows 72f336434448…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2486: PARP1 in dopamine neurons, braak

power
full sample +0.08 (p 0.748, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.04 (p 0.881, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.08 (p 0.754, n 18). could be the mix.
skeptic
leave-one-out range -0.03 to +0.22, sign flips 2; without severely affected donors +0.08 (p 0.748, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PARP1 in dopamine neurons.

case closed: nothing better to follow up.