Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2402

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.45, p 0.227). This receipt's hash covers every field on it, plus the hash of receipt 2401, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2402
    18 Oct 2026, 21:16 UTC

    SIRT2

    oligodendrocytes, braak

    predictionSIRT2 in oligodendrocytes tracks Braak Lewy-body stage

    registered3b88607b352a5809

    discovery-0.45 p=0.227 n=9

    replication+0.20 p=0.602 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.45, p 0.227)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    357fbef7dcbad2fe6499d990…
    follows fc2a1817fad3…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2402: SIRT2 in oligodendrocytes, braak

power
full sample -0.16 (p 0.521, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.31 (p 0.207, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.26 (p 0.302, n 18). could be the mix.
skeptic
leave-one-out range -0.30 to -0.06, sign flips 0; without severely affected donors -0.16 (p 0.521, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SIRT2 in oligodendrocytes.

case closed: nothing better to follow up.