Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0232

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.53, p 0.145). This receipt's hash covers every field on it, plus the hash of receipt 231, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0232
    16 Oct 2026, 19:46 UTC

    HIP1R

    dopamine neurons, braak

    predictionHIP1R in dopamine neurons tracks Braak Lewy-body stage

    registereddf430c332199e821

    discovery-0.53 p=0.145 n=9

    replication-0.55 p=0.122 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.53, p 0.145)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6a2ff7ceb6c8a1f068a137f3…
    follows afc5bb1b8101…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0232: HIP1R in dopamine neurons, braak

power
full sample -0.51 (p 0.029, n 18), 95% CI -0.79 to -0.06. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.53 (p 0.025, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.027, n 18). not the mix.
skeptic
leave-one-out range -0.68 to -0.44, sign flips 0; without severely affected donors -0.51 (p 0.029, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for HIP1R in dopamine neurons.

case closed: nothing better to follow up.