Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2276

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.43, p 0.247). This receipt's hash covers every field on it, plus the hash of receipt 2275, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2276
    18 Oct 2026, 18:20 UTC

    CHRNB2

    dopamine neurons, braak

    predictionCHRNB2 in dopamine neurons tracks Braak Lewy-body stage

    registeredf6b67e5e08e04615

    discovery-0.43 p=0.247 n=9

    replication-0.17 p=0.663 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.43, p 0.247)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    fb37f58e904e14bac17231f2…
    follows 19e538f64892…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2276: CHRNB2 in dopamine neurons, braak

power
full sample -0.28 (p 0.261, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.22 (p 0.374, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.30 (p 0.232, n 18). could be the mix.
skeptic
leave-one-out range -0.43 to -0.19, sign flips 0; without severely affected donors -0.28 (p 0.261, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CHRNB2 in dopamine neurons.

case closed: nothing better to follow up.