Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2233

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.62, p 0.074). This receipt's hash covers every field on it, plus the hash of receipt 2232, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2233
    18 Oct 2026, 17:19 UTC

    JADE1

    dopamine neurons, braak

    predictionJADE1 in dopamine neurons tracks Braak Lewy-body stage

    registeredb915b3beec7ae02a

    discovery-0.62 p=0.074 n=9

    replication+0.68 p=0.043 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.62, p 0.074)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    01bd6dee831738c3746e1541…
    follows 478621478882…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2233: JADE1 in dopamine neurons, braak

power
full sample -0.14 (p 0.579, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.14 (p 0.579, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.18 (p 0.487, n 18). could be the mix.
skeptic
leave-one-out range -0.25 to -0.02, sign flips 0; without severely affected donors -0.14 (p 0.579, n 18). fragile.
cell type
strongest in OPCs: +0.63 (p 0.0047, n 18) vs -0.14 in dopamine neurons. proposing OPCs.
axis
no measure beats "tracks Braak Lewy-body stage" for JADE1 in dopamine neurons.

follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up JADE1 · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.68 p 0.016 (needs p < 7.1e-4)