Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2204

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.61, p 0.083). This receipt's hash covers every field on it, plus the hash of receipt 2203, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2204
    18 Oct 2026, 16:41 UTC

    PRSS53

    dopamine neurons, braak

    predictionPRSS53 in dopamine neurons tracks Braak Lewy-body stage

    registeredc616c535b96618e1

    discovery-0.61 p=0.083 n=9

    replication-0.29 p=0.443 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.61, p 0.083)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    edcd7fe58b4f91a83e979977…
    follows 3fa3fcf466b6…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2204: PRSS53 in dopamine neurons, braak

power
full sample -0.46 (p 0.057, n 18), 95% CI -0.76 to +0.01. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.49 (p 0.041, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.022, n 18). not the mix.
skeptic
leave-one-out range -0.61 to -0.39, sign flips 0; without severely affected donors -0.46 (p 0.057, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PRSS53 in dopamine neurons.

case closed: nothing better to follow up.