Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2180

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.14, p 0.716). This receipt's hash covers every field on it, plus the hash of receipt 2179, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2180
    18 Oct 2026, 16:05 UTC

    GFOD1

    dopamine neurons, braak

    predictionGFOD1 in dopamine neurons tracks Braak Lewy-body stage

    registereda23a105427502404

    discovery-0.14 p=0.716 n=9

    replication-0.36 p=0.347 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.14, p 0.716)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    d13334962a84394605f98e4d…
    follows b22b7edabf49…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2180: GFOD1 in dopamine neurons, braak

power
full sample -0.30 (p 0.221, n 18), 95% CI -0.67 to +0.19. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.30 (p 0.221, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.47 (p 0.050, n 18). not the mix.
skeptic
leave-one-out range -0.44 to -0.21, sign flips 0; without severely affected donors -0.30 (p 0.221, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GFOD1 in dopamine neurons.

case closed: nothing better to follow up.