Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2162

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.06, p 0.888). This receipt's hash covers every field on it, plus the hash of receipt 2161, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2162
    18 Oct 2026, 15:38 UTC

    EPHB1

    astrocytes, braak

    predictionEPHB1 in astrocytes tracks Braak Lewy-body stage

    registeredd5a975f548332430

    discovery-0.06 p=0.888 n=9

    replication+0.12 p=0.749 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.06, p 0.888)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    c4b2ffed45d11b477a104997…
    follows c77acb978c2f…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2162: EPHB1 in astrocytes, braak

power
full sample +0.13 (p 0.615, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.15 (p 0.555, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.11 (p 0.658, n 18). could be the mix.
skeptic
leave-one-out range +0.03 to +0.27, sign flips 0; without severely affected donors +0.13 (p 0.615, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for EPHB1 in astrocytes.

case closed: nothing better to follow up.