Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 2110

A sealed prediction that did not hold.

did not replicate (discovery -0.76 p 0.019; held-out +0.32 p 0.407). This receipt's hash covers every field on it, plus the hash of receipt 2109, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 2110
    18 Oct 2026, 14:21 UTC

    TNR

    oligodendrocytes, braak

    predictionTNR in oligodendrocytes tracks Braak Lewy-body stage

    registered595ef28ac8364de7

    discovery-0.76 p=0.019 n=9

    replication+0.32 p=0.407 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.76 p 0.019; held-out +0.32 p 0.407)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    99ba0e6046dac04a0a474d68…
    follows 0e1b7b26ceb0…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 2110: TNR in oligodendrocytes, braak

power
full sample -0.25 (p 0.315, n 18), 95% CI -0.64 to +0.24. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.25 (p 0.315, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.31 (p 0.204, n 18). could be the mix.
skeptic
leave-one-out range -0.39 to -0.16, sign flips 0; without severely affected donors -0.25 (p 0.315, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TNR in oligodendrocytes.

case closed: nothing better to follow up.