Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1994

A sealed prediction that did not hold.

did not replicate (discovery -0.94 p 2.1e-4; held-out -0.10 p 0.807). This receipt's hash covers every field on it, plus the hash of receipt 1993, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1994
    18 Oct 2026, 11:27 UTC

    PCGF2

    dopamine neurons, braak

    predictionPCGF2 in dopamine neurons tracks Braak Lewy-body stage

    registered661d75f01b5572d5

    discovery-0.94 p=2.1e-4 n=9

    replication-0.10 p=0.807 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.94 p 2.1e-4; held-out -0.10 p 0.807)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    78357af758b1b63f35a364fc…
    follows f418768c9151…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1994: PCGF2 in dopamine neurons, braak

power
full sample -0.60 (p 0.0080, n 18), 95% CI -0.84 to -0.19. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.61 (p 0.0075, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.71 (p 0.0010, n 18). not the mix.
skeptic
leave-one-out range -0.74 to -0.56, sign flips 0; without severely affected donors -0.60 (p 0.0080, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PCGF2 in dopamine neurons.

case closed: nothing better to follow up.