Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1913

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.61, p 0.078). This receipt's hash covers every field on it, plus the hash of receipt 1912, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1913
    18 Oct 2026, 09:32 UTC

    ISOC2

    dopamine neurons, braak

    predictionISOC2 in dopamine neurons tracks Braak Lewy-body stage

    registered584c9e88125943f2

    discovery+0.61 p=0.078 n=9

    replication-0.05 p=0.893 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.61, p 0.078)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    052bbffb6628d6dca2c27418…
    follows af30d486ab28…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1913: ISOC2 in dopamine neurons, braak

power
full sample +0.31 (p 0.218, n 18), 95% CI -0.19 to +0.68. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.31 (p 0.211, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.31 (p 0.211, n 18). could be the mix.
skeptic
leave-one-out range +0.21 to +0.42, sign flips 0; without severely affected donors +0.31 (p 0.218, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ISOC2 in dopamine neurons.

case closed: nothing better to follow up.