Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 1875

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.33, p 0.380). This receipt's hash covers every field on it, plus the hash of receipt 1874, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 1875
    18 Oct 2026, 08:34 UTC

    FRMD4A

    dopamine neurons, braak

    predictionFRMD4A in dopamine neurons tracks Braak Lewy-body stage

    registered5b13967a38576212

    discovery-0.33 p=0.380 n=9

    replication-0.32 p=0.407 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.33, p 0.380)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    6462c5cc08e23305fabb82ce…
    follows 990ad00dcfbc…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 1875: FRMD4A in dopamine neurons, braak

power
full sample -0.39 (p 0.111, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.38 (p 0.123, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.031, n 18). not the mix.
skeptic
leave-one-out range -0.49 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.111, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for FRMD4A in dopamine neurons.

case closed: nothing better to follow up.