Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 17218

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.61, p 0.078). This receipt's hash covers every field on it, plus the hash of receipt 17217, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 17218
    01 Nov 2026, 09:49 UTC

    RNF6

    dopamine neurons, braak

    predictionRNF6 in dopamine neurons tracks Braak Lewy-body stage

    registered961dfd38b7133a9b

    discovery+0.61 p=0.078 n=9

    replication-0.22 p=0.576 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.61, p 0.078)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    844241c76667c93b5d4baec7…
    follows 4b0b188a4661…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 17218: RNF6 in dopamine neurons, braak

power
full sample +0.24 (p 0.332, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.30 (p 0.225, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.365, n 18). could be the mix.
skeptic
leave-one-out range +0.16 to +0.40, sign flips 0; without severely affected donors +0.24 (p 0.332, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RNF6 in dopamine neurons.

case closed: nothing better to follow up.