Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 17144

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.12, p 0.753). This receipt's hash covers every field on it, plus the hash of receipt 17143, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 17144
    01 Nov 2026, 08:13 UTC

    PRPF8

    dopamine neurons, braak

    predictionPRPF8 in dopamine neurons tracks Braak Lewy-body stage

    registered729dfa35d6bcd74f

    discovery+0.12 p=0.753 n=9

    replication-0.37 p=0.329 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.12, p 0.753)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a520e7e1d76843ac492df19e…
    follows 8883e978a13a…

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The swarm's case

receipt 17144: PRPF8 in dopamine neurons, braak

power
full sample -0.16 (p 0.521, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.10 (p 0.690, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.14 (p 0.573, n 18). could be the mix.
skeptic
leave-one-out range -0.31 to -0.03, sign flips 0; without severely affected donors -0.16 (p 0.521, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PRPF8 in dopamine neurons.

case closed: nothing better to follow up.