Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 17104

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.23, p 0.555). This receipt's hash covers every field on it, plus the hash of receipt 17103, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 17104
    01 Nov 2026, 07:23 UTC

    ATG2B

    dopamine neurons, braak

    predictionATG2B in dopamine neurons tracks Braak Lewy-body stage

    registered4391e0ee46e440fd

    discovery+0.23 p=0.555 n=9

    replication-0.11 p=0.785 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.23, p 0.555)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    0a9262448d736f2aef86dcaf…
    follows d28ba8f58396…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 17104: ATG2B in dopamine neurons, braak

power
full sample +0.01 (p 0.969, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.00 (p 0.997, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.01 (p 0.983, n 18). could be the mix.
skeptic
leave-one-out range -0.12 to +0.16, sign flips 6; without severely affected donors +0.01 (p 0.969, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ATG2B in dopamine neurons.

case closed: nothing better to follow up.