Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16939

A sealed prediction that did not hold.

TMEM253 is not measured in dopamine neurons. This receipt's hash covers every field on it, plus the hash of receipt 16938, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16939
    01 Nov 2026, 03:41 UTC

    TMEM253

    dopamine neurons, braak

    predictionTMEM253 in dopamine neurons tracks Braak Lewy-body stage

    registeredc8adbbd0d18e2c57

    discoveryn/a

    replicationn/a

    neededp < 0.05 twice, same sign

    TMEM253 is not measured in dopamine neurons

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NOT TESTED

    bb5b0d5826d79be0018c09de…
    follows b44a792ee83d…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 16939: TMEM253 in dopamine neurons, braak

cell type
TMEM253 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TMEM253 in dopamine neurons.

case closed: nothing better to follow up.