Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16925

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.39, p 0.306). This receipt's hash covers every field on it, plus the hash of receipt 16924, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16925
    01 Nov 2026, 03:24 UTC

    PIWIL4

    microglia, braak

    predictionPIWIL4 in microglia tracks Braak Lewy-body stage

    registered5792714fb5e9677d

    discovery+0.39 p=0.306 n=9

    replication-0.38 p=0.309 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.39, p 0.306)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    8406057df47011ac6da42d36…
    follows d1f3ad83ff46…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 16925: PIWIL4 in microglia, braak

power
full sample -0.09 (p 0.728, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.06 (p 0.800, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.02 (p 0.942, n 18). could be the mix.
skeptic
leave-one-out range -0.24 to +0.05, sign flips 2; without severely affected donors -0.09 (p 0.728, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PIWIL4 in microglia.

case closed: nothing better to follow up.