Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16849

A sealed prediction that did not hold.

did not replicate (discovery -0.67 p 0.047; held-out -0.37 p 0.334). This receipt's hash covers every field on it, plus the hash of receipt 16848, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16849
    01 Nov 2026, 02:23 UTC

    KLK1

    dopamine neurons, braak

    predictionKLK1 in dopamine neurons tracks Braak Lewy-body stage

    registered84bb00ee61da31d8

    discovery-0.67 p=0.047 n=9

    replication-0.37 p=0.334 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.67 p 0.047; held-out -0.37 p 0.334)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    d7f2fdba2e1b591a9dd01405…
    follows 037dcc2ce5c7…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 16849: KLK1 in dopamine neurons, braak

power
full sample -0.49 (p 0.041, n 18), 95% CI -0.78 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.51 (p 0.030, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.71 (p 0.0011, n 18). not the mix.
skeptic
leave-one-out range -0.64 to -0.42, sign flips 0; without severely affected donors -0.49 (p 0.041, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KLK1 in dopamine neurons.

case closed: nothing better to follow up.