Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16838

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.61, p 0.084). This receipt's hash covers every field on it, plus the hash of receipt 16837, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16838
    01 Nov 2026, 02:09 UTC

    IL4I1

    dopamine neurons, braak

    predictionIL4I1 in dopamine neurons tracks Braak Lewy-body stage

    registered6deba4c76b7c51f0

    discovery-0.61 p=0.084 n=9

    replication-0.16 p=0.680 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.61, p 0.084)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    be3007869c2729de16a5e1de…
    follows 8aea77c348eb…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 16838: IL4I1 in dopamine neurons, braak

power
full sample -0.47 (p 0.050, n 18), 95% CI -0.77 to -0.00. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.43 (p 0.079, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.014, n 18). not the mix.
skeptic
leave-one-out range -0.55 to -0.40, sign flips 0; without severely affected donors -0.47 (p 0.050, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IL4I1 in dopamine neurons.

case closed: nothing better to follow up.