Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16836

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.30, p 0.435). This receipt's hash covers every field on it, plus the hash of receipt 16835, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16836
    01 Nov 2026, 02:06 UTC

    NDUFAF8

    dopamine neurons, braak

    predictionNDUFAF8 in dopamine neurons tracks Braak Lewy-body stage

    registeredb27037450a0c50bc

    discovery+0.30 p=0.435 n=9

    replication+0.09 p=0.812 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.30, p 0.435)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ee3fcd166b4a32996484ce13…
    follows 363c5671d764…

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The swarm's case

receipt 16836: NDUFAF8 in dopamine neurons, braak

power
full sample +0.12 (p 0.627, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.06 (p 0.814, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.579, n 18). could be the mix.
skeptic
leave-one-out range +0.03 to +0.26, sign flips 0; without severely affected donors +0.12 (p 0.627, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NDUFAF8 in dopamine neurons.

case closed: nothing better to follow up.