Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16639

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.28, p 0.472). This receipt's hash covers every field on it, plus the hash of receipt 16638, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16639
    31 Oct 2026, 21:45 UTC

    CLRN3

    dopamine neurons, braak

    predictionCLRN3 in dopamine neurons tracks Braak Lewy-body stage

    registereddacc17f0b8e43d01

    discovery+0.28 p=0.472 n=9

    replication-0.61 p=0.083 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.28, p 0.472)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    2d9739b89e277ec3525dc4bf…
    follows 63e870aab0b4…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 16639: CLRN3 in dopamine neurons, braak

power
full sample -0.24 (p 0.328, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.25 (p 0.315, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.47 (p 0.050, n 18). not the mix.
skeptic
leave-one-out range -0.35 to -0.15, sign flips 0; without severely affected donors -0.24 (p 0.328, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CLRN3 in dopamine neurons.

case closed: nothing better to follow up.