Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16566

A sealed prediction that did not hold.

did not replicate (discovery -0.78 p 0.013; held-out +0.22 p 0.563). This receipt's hash covers every field on it, plus the hash of receipt 16565, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16566
    31 Oct 2026, 20:10 UTC

    XPNPEP1

    dopamine neurons, braak

    predictionXPNPEP1 in dopamine neurons tracks Braak Lewy-body stage

    registeredfb11dd2453bc861d

    discovery-0.78 p=0.013 n=9

    replication+0.22 p=0.563 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.78 p 0.013; held-out +0.22 p 0.563)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    967bbc89a9fc47e86e52eb7b…
    follows e0c462396896…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 16566: XPNPEP1 in dopamine neurons, braak

power
full sample -0.18 (p 0.471, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.22 (p 0.389, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.22 (p 0.384, n 18). could be the mix.
skeptic
leave-one-out range -0.33 to -0.09, sign flips 0; without severely affected donors -0.18 (p 0.471, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for XPNPEP1 in dopamine neurons.

case closed: nothing better to follow up.