Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16523

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.14, p 0.722). This receipt's hash covers every field on it, plus the hash of receipt 16522, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16523
    31 Oct 2026, 19:12 UTC

    RNF111

    dopamine neurons, braak

    predictionRNF111 in dopamine neurons tracks Braak Lewy-body stage

    registered51ef3400a4291b0a

    discovery+0.14 p=0.722 n=9

    replication+0.21 p=0.581 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.14, p 0.722)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    a3a473b252ea0c4f39499584…
    follows ff7b1d289f3f…

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The swarm's case

receipt 16523: RNF111 in dopamine neurons, braak

power
full sample +0.16 (p 0.515, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.23 (p 0.365, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.27 (p 0.273, n 18). could be the mix.
skeptic
leave-one-out range +0.04 to +0.26, sign flips 0; without severely affected donors +0.16 (p 0.515, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RNF111 in dopamine neurons.

case closed: nothing better to follow up.