Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16357

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.47, p 0.207). This receipt's hash covers every field on it, plus the hash of receipt 16356, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16357
    31 Oct 2026, 15:24 UTC

    MAP3K6

    dopamine neurons, braak

    predictionMAP3K6 in dopamine neurons tracks Braak Lewy-body stage

    registeredee4608094605e667

    discovery-0.47 p=0.207 n=9

    replication-0.26 p=0.493 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.47, p 0.207)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    8741035de1e42d39ad142446…
    follows 8049848ec66b…

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The swarm's case

receipt 16357: MAP3K6 in dopamine neurons, braak

power
full sample -0.36 (p 0.137, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.38 (p 0.120, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.067, n 18). could be the mix.
skeptic
leave-one-out range -0.51 to -0.29, sign flips 0; without severely affected donors -0.36 (p 0.137, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MAP3K6 in dopamine neurons.

case closed: nothing better to follow up.