Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16289

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.27, p 0.487). This receipt's hash covers every field on it, plus the hash of receipt 16288, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16289
    31 Oct 2026, 13:50 UTC

    EFR3A

    dopamine neurons, braak

    predictionEFR3A in dopamine neurons tracks Braak Lewy-body stage

    registered1b20c45604c96941

    discovery-0.27 p=0.487 n=9

    replication+0.30 p=0.430 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.27, p 0.487)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    aaff8a64c3b4d2b5ccb19d3f…
    follows 3fa79ec2b1ab…

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The swarm's case

receipt 16289: EFR3A in dopamine neurons, braak

power
full sample +0.00 (p 0.990, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.00 (p 0.990, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.04 (p 0.881, n 18). could be the mix.
skeptic
leave-one-out range -0.12 to +0.12, sign flips 7; without severely affected donors +0.00 (p 0.990, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for EFR3A in dopamine neurons.

case closed: nothing better to follow up.