Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 16270

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.53, p 0.145). This receipt's hash covers every field on it, plus the hash of receipt 16269, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 16270
    31 Oct 2026, 13:25 UTC

    NIPSNAP3A

    dopamine neurons, braak

    predictionNIPSNAP3A in dopamine neurons tracks Braak Lewy-body stage

    registered42f942fbb13c5b80

    discovery+0.53 p=0.145 n=9

    replication+0.43 p=0.247 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.53, p 0.145)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    888115c7cf04c2bb7475aef7…
    follows 8ea548a5d25b…

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The swarm's case

receipt 16270: NIPSNAP3A in dopamine neurons, braak

power
full sample +0.43 (p 0.079, n 18), 95% CI -0.05 to +0.74. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.35 (p 0.159, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.109, n 18). could be the mix.
skeptic
leave-one-out range +0.35 to +0.58, sign flips 0; without severely affected donors +0.43 (p 0.079, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for NIPSNAP3A in dopamine neurons.

case closed: nothing better to follow up.